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The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof.
I mean you can refute or ignore it if you'd like. The isolated DNA encoding the VL region can be converted to a full-length light chain gene (as well as a Fab light chain gene) by operatively linking the VL-encoding DNA to another DNA molecule encoding the light chain constant region, CL.
Sci. (USA) 97:722-727. Furthermore, cows carrying human heavy and light chain transchromosomes have been described in the art (Kuroiwa et al. Still further, alternative transgenic animal systems expressing human immunoglobulin genes are available in the art and can be used to raise anti-huCD40 antibodies described herein. The HuMAb Mouse.RTM.

(MEDAREX, Inc.) contains human immunoglobulin gene miniloci that encode unrearranged human heavy (.mu. In certain embodiments, antibodies described herein are raised using a mouse that carries human immunoglobulin sequences on transgenes and transchromosomes, such as a mouse that carries a human heavy chain transgene and a human light chain transchromosome.
In another preferred embodiment, antibodies are selected that have minimal aggre*** effects, which can lead to the triggering of an unwanted immune response and/or altered or unfavorable pharmacokinetic properties.

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