In other embodiments, a binding site of a molecule of the invention comprises an antigen binding portion of an antibody.
In one embodiment, a molecule of the invention comprises at least one of a therapeutic molecule that is an antigen binding site (e.g., an antigen binding site of an antibody, antibody variant, or antibody fragment), a receptor binding portion of ligand, or a ligand binding portion of a receptor.
In one embodiment, a behavioral score is obtained with a novel object recognition test. In still other embodiments, the method comprising a calcium oscillation assay, a sequence score method, and/or in vivo tolerability test can further comprise administering the selected molecule to a subject in need thereof.
In still other embodiments, a molecule useful for the invention binds to a molecule which is useful in treating an autoimmune or inflammatory disease or disorder. In certain embodiments, the disease or condition is progressive supranuclear palsy, Down syndrome, dementia pugilistica (chronic traumatic encephalopathy and other traumatic brain injury), frontotempotal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Lytico-Bodig disease (Parkinson-dementia complex of Guam), Tangle-predominant dementia, ganglioglioma, gangliocytoma, meningioangiomatosis, subacute sclerosing panencephalitis, lead encephalopathy, Hemimegalencephaly, tuberous sclerosis, Hallervorden-Spatz disease, Pick's disease, corticobasal ganglionic degeneration, argyrophilic grain disease, corticobasal degeneration, lipofuscinosis, frontotemporal dementia, supranuclear palsy, and frontotemporal lobar degeneration, a disease of brain network dysfunction (e.g., all forms of epilepsy and depression), dravet syndrome, a spinal cord disorder, a peripheral neuropathy, a cranial nerve disorder (e.g., Trigeminal neuralgia), an autonomic nervous system disorder (e.g., dysautonomia or multiple system atrophy), a movement disorder of a central and peripheral nervous system (e.g., Parkinson's disease, essential tremor, amyotrophic lateral sclerosis, Tourette's Syndrome, multiple sclerosis or various types of peripheral neuropathy), a sleep disorder (e.g., Narcolepsy), migraine or other types of headache (e.g., cluster headache and tension headache), lower back and neck pain, central neuropathy, a neuropsychiatric illness, attention de***it hyperactivity disorder, autism, Huntington's disease, Rett Syndrome, Angelman syndrome, organic psychosis, an infection of the brain or spinal cord (including meningitis), or a prion disease), anemia, cancer, leukemia, an inflammatory condition or an autoimmune disease (e.g.
arthritis, psoriasis, lupus erythematosus, multiple sclerosis), a bacterial infection, and any combination thereof.
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