Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, and liposome-containing formulations.
Such moieties include, but are not limited to, antibodies, polypeptides, lipid moieties such as a cholesterol moiety, cholic acid, a thioether. These compositions may be generated from a variety of components that include, but are not limited to, preformed liquids, self-emulsifying solids and self-emulsifying semisolids.
Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable. The therapeutic molecules of the invention can be used in pharmaceutical formulations and compositions. The nucleotides of the oligomer of the invention or contiguous nucleotides sequence thereof can be coupled together via linkage groups.
In some embodiments, the oligomer of the invention comprises at least one LNA unit or at least one 2' substituted modified nucleoside. The oligomers of the invention can therefore have at least one bicyclic nucleoside attached to the 3' or 5' termini by a neutral internucleoside linkage, such as one or more phosphotriester, methylphosphonate, MMI, amide-3, formacetal or thioformacetal.
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