These mice express wild-type deer or PrPC harboring the S138N substitution ***- or heterozygously, a polymorphism identified solely in reindeer (Rangifer tarandus spp.) and fallow deer (Dama dama).
Brain ***genates (10% w/v) from the raccoon and the two white-tailed deer have been utilized to intracranially inoculate different teams of transgenic mice that express human prion protein with methionine (M) at codon 129 (Tg40h). We have recognized prion protein variants in the white-tailed deer population and demonstrated that Prnp genotype affects the susceptibility/disorder development of white-tailed deer to CWD agent.
click through the next post existence of cervid prion protein variants raises the likelihood of distinctive CWD strains. Furthermore, our ***yze gives new mechanistic insights into genetic resistance and dominant-destructive interference of conversion-pro***ient PrP variants.
Our effects present new mechanistic insights into dominant-destructive inhibition of prion conversion, the tissue speci***ity of this impact, and indicates that PrPC key structure is a determinant for tissue-speci*** prion replication.